Nicotinamide Mononucleotide Supplementation Improves Mitochondrial Dysfunction and Reduces Cellular Senescence
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Older mesenchymal stem cells (MSCs) displayed lower NAD+ content, reduced SIRT3 expression, and mitochondrial dysfunction, which were ameliorated by NMN administration.
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NMN supplementation led to significant increases in intracellular NAD+ level, NAD+/ NADH ratio, Sirt3 expression, as well as ameliorated mitochondrial function and rescued senescent MSCs.
This study was published in November 2022 in the International Journal of Molecular Sciences:
Study abstract excerpt: